SGLT2 Inhibitors - Mechanism of Action - Regner Health Solutions


The mechanism of action of SGLT2 inhibitors involves blocking glucose reabsorption in the kidneys, thereby increasing the amount of glucose excreted in the urine. By preventing glucose reabsorption, these medications help to lower blood sugar levels and improve glycemic control in individuals with diabetes. In addition to their effects on glucose reabsorption, SGLT2 inhibitors also have other benefits. They have been shown to impact the renin-angiotensin-aldosterone system, which plays a role in regulating blood pressure. By inhibiting SGLT2, these medications reduce sodium reabsorption in the kidneys, reducing fluid retention and blood pressure. This, in turn, can help to reduce the afterload and preload on the heart, improving cardiac function. Furthermore, SGLT2 inhibitors have been shown to affect cardiac fuel metabolism positively. They increase the utilization of fatty acids as an energy source for the heart, improving myocardial efficiency and reducing the risk of cardiac complications. Another benefit of SGLT2 inhibitors is their potential for nephroprotection. Reducing glucose reabsorption in the kidneys and increasing glucose excretion can help lower the risk of kidney damage and slow the progression of diabetic nephropathy. Learn more about SGLT2 inhibitors and other services we offer: regnerhealthsolutions.com/sglt2-inhibitors/

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